Acting Downstream of Cytochrome P450 Cholesterol Metabolism: the Main Pathway
نویسندگان
چکیده
Published Ahead of Print 9 March 2009. 10.1128/MCB.01638-08. 2009, 29(10):2716. DOI: Mol. Cell. Biol. Wolf and Cheryll Tickle Gundersen, Rune Blomhoff, Colin Henderson, C. Roland Goodyear, Richard M. Aspden, Richard Talbot, Thomas E. Katy Schmidt, Catherine Hughes, J. A. Chudek, Simon R. the Limb Oxidoreductase in Skeletal Development of Acting Downstream of Cytochrome P450 Cholesterol Metabolism: the Main Pathway
منابع مشابه
Cholesterol metabolism: the main pathway acting downstream of cytochrome P450 oxidoreductase in skeletal development of the limb.
Cytochrome P450 oxidoreductase (POR) is the obligate electron donor for all microsomal cytochrome P450 enzymes, which catalyze the metabolism of a wide spectrum of xenobiotic and endobiotic compounds. Point mutations in POR have been found recently in patients with Antley-Bixler-like syndrome, which includes limb skeletal defects. In order to study P450 function during limb and skeletal develop...
متن کاملEffects of probiotic Lactobacillus paracasei TD3 on moderation of cholesterol biosynthesis pathway in rats
Objective(s): Prevalence of high-fat food consumption, such as fast foods is one of the major causes of hypercholesterolemia, which can lead to cardiovascular diseases. 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and cytochrome P450 7A1 (CYP7A1) are two key genes in cholesterol metabolism. Use of probiotics in the diet is a promising approach for modulation...
متن کاملExpression of cytochrome P450 and glutathione S-transferase in human bone marrow mesenchymal stem cells
Currently several studies are being carried out on various properties of mesenchymal stem cells (MSCs)however there are a few investigations about drug metabolizing properties of these cells. The aim of thisstudy was to measure the key factors involved in drug metabolism in human bone marrow MSCs. For thispurpose, cellular glutathione (GSH), glutathione Stransferase (GSTs) and...
متن کاملInactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.
Cytochrome P450 (CYP) monooxygenases catalyze the oxidation of a large number of endogenous compounds and the majority of ingested environmental chemicals, leading to their elimination and often to their metabolic activation to toxic products. This enzyme system therefore provides our primary defense against xenobiotics and is a major determinant in the therapeutic efficacy of pharmacological a...
متن کاملDap1/PGRMC1 binds and regulates cytochrome P450 enzymes.
Cytochrome P450 enzymes are heme-dependent monoxygenases that play a central role in human physiology. Despite the numerous physiological processes that P450 enzymes impact, the electron donors P450 oxidoreductase and cytochrome b5 are the only proteins known to interact with and modulate the activity of ER microsomal P450s. Here, we report that Dap1/PGRMC1 is required for ER P450 function in y...
متن کامل